Gilbert’s Syndrome and High Bilirubin: Learn Hidden Cause of Gut/Brain Issues
What is Gilbert’s Syndrome? Gilbert’s Syndrome is caused by reduced activity of the UGT1A1 enzyme, the key pathway responsible for conjugating (detoxifying) bilirubin so it can be safely excreted from the body. Most patients have a promoter variant that decreases enzyme efficiency by up to 70%. This lower enzyme activity doesn’t just affect bilirubin. UGT1A1—and … Read more